Top Five - all along Southern I-95 to plug three different ~100 mile gaps:
Emporia, VA
Roanoke Rapids, NC (1+2 can fill the 107 mile gap on I-95 between Chester, VA and Rocky Mount, NC.)
Walterboro, SC
Hardeeville, SC (3+4 can fill the 108mile gap on I-95 between Santee, SC and Savana, GA...