I have 22" non-standard wheels on my 2015 Model S. I love the looks. The car drives perfect - feels a lot confident in corners when compared with the stock 18" wheels that the car came with - I still have those in the garage.
However, there are 2 things:
1. The TPMS warning remains - it says tire pressure monitoring is not working because the supported configuration is only up to 21". I took the car to the service center and they told me to ignore the message and that its not going to cause problems. They also told me they can remove the messaging for me but it will require about 2 hrs of work. I havent taken in the car yet for that to happen.
2. The ride is obviously stiffer. You will feel a lot more road than compared with the stock 18" wheels which was definitely noticeably softer / cushiony (does this word exist)?
And I believe the power consumption per mile is also more with the 22" wheels compared to the stock.
But having driven motorcycles, I dont car about the softer / firmer drive. I love the feel of the road and the looks... See for yourself...