Reporting back on this thread since I've had the wheels on for a few months now.
Efficiency: Definitely noticed some gains on the highway. Part of my trip (flat), I was able to get below 360 Wh/mi @ 75 mph (few hours). It's been cold here, so the Wh/mi have been all over the place (mostly on the high side (500+ Wh/mi). I'm attributing this to the constant short commutes that I take and the amount of energy consumed just to heat the battery.
Ride quality: Nothing noticeable, but I've gone over a couple of potholes inadvertently and didn't think that it felt as if I destroyed the wheels.
Looks: The 22's make the X look a bit more aggressive and the wider wheels in the rear simply make it stand out even more. 20's make the X look a bit more like a regular CUV/SUV.
Verdict: No issues noted with the square setup (265/45/20), so I'll keep this additional set for winter time usage.