I keep the PSI to 43. I believe that's the suggested inflation, although I'll admit I haven't referred to the specifications. Tesla vehicles typically run tire inflation levels higher than ICE vehicles, from my experience. I cannot comment on range. I bought my vehicle with the 20" wheels and then upgraded to 22". Although there is talk of a range penalty, I haven't tested this. Nor have I found the 22" wheels to offer a harsher ride than the 20". I'm sure they do, but I cannot say I have experienced or noticed a difference.