Had my 12V replaced once in 4 years. Got a warning message that 12v was in need of replacement, and to schedule appointment to replace it. Tesla said that after the message pops up you have about 1 week before the 12v battery dies (the car monitors the 12v's state of health), so it isn't like it just happens out of the blue.
The inconvenience isn't really the issue. This doesn't look like a cheap battery to replace.