Out of 30 years driving I needed to put a spare tire on four times that I can think of. Two were catastrophic blow outs and two were slow leaks that I didn't notice until I got out of work.
Both blow outs were due to our terrible roads in California. One was on a trailer and I noticed a pothole at the last minute and I couldn't swerve without causing a larger incident. The blow out destroyed the rim on my trailer, that destroyed rim actually helped catch a guy breaking into cars in my neighborhood so some good came out of it. The second was partially my fault and I will blame the terrible road conditions here. I took a long trip and didn't notice that my wifes car tread was a tad low. I hit an extremely rough patch on the highway and it caused one of my tires go.
Don't run your tires bald and avoid pot holes and you should be ok. I will probably get the slime compressor for my car.