Since the Model S needs to operate properly even in the case of faulty items, such as door locks, sunroof, etc. the propulsion system is probably quite isolated and should function in the absence of those items.
I'm pretty sure this is the case and the car will do its best to run and charge if it can do so safely.
On the other hand, I'm hoping to get over the air system updates and the current one is failing to stick. I'm guessing it's failing since I have a number of systems disconnected (SRS, HVAC, Stability control). It seems the simplest solution is to use all the original systems, even if the door handles just sit wired up in a box at first.
Zextraterrestrial: By early summer I hope to be meeting up with people at my Supercharger stops!