It most often will if the tire is not being crushed. Sometimes you have to lift and wiggle to get some seal. You might have to hold it in the position a lot longer with a wimpy compressor. And even a high flow compressor won’t work if there isn’t a partial seal.The beads don't always break when a tire goes flat. If the bead is broken, it's doubtful a 12V compressor will be effective. Otherwise I'd say it will work.