The problem with tinning is that solder is soft. If the thick heavy gauge wire isn't heated sufficiently, the solder just sticks to it, as opposed to bonding with it. The strands are still independent, and can move independently. Depending on the situation, the solder can soften / crack / compress / detach from the copper, and the connection will become loose. Loose wires / loose connections create resistance. Resistance creates heat. Heat creates fires. In general, with screw type connectors, use solidcore wire or put ferrule connectors on the ends of stranded wire.
Not specific to our exact use case, but similar enough for a good example...
To Ferrule or Not to Ferrule?