Yes aftermarket portable TPMS for me would be a must. But sometimes you could be in a position where you can't pull over. Worst case scenario would be going fast in a tunnel with traffic.
Well maybe yet another solution would be a second set of wheels and axles (Perhaps smaller if weight saving is a major concern) normally are not in contact with the ground perhaps an inch or so off the ground but can pivot down when rapid depressurization happens. That way you have little tire wear, have the ability to chock when parked, and like in an inline skate while going over a obstacle the raised tire helps like a ramp. You don't have to worry about where to store a spare tire as you always have two spares ready to go instantly. But I was reading about the Avion trailers which have triple axles and they apparently tow extremely nicely and supposedly are less prone to trailer sway.
In the case of a triple axle with power to some or all of the wheels, you would have almost tank like ability to get the trailer over things.
