As far as I'm concerned, the system should have one setting: If a car's tire is about to cross a road marker/line, it should act like a rumble strip. If your driving style takes you over a line, it should rumble. If you're on a rural two-way road and you need to cross a line, it should rumble. In both of these situations, however safe you may be driving, you're not using the road as intended. Yes, we may all do it, but until sophisticated object detection is in place, it has to assume the worst to be most effective. Just as real-world rumble strips would always "activate" if you swerved to avoid an obstacle, the lane departure shouldn't be forgiving. After all, where does it stop? A foot over the line? Five feet over the line? This is all leading toward automation and needs to follow the rules of the road. Because you know that OTHER car coming toward me in a two lane road, momentarily distracted for some random reason? I sure wouldn't want them to have a "low sensitivity" setting.
Now, I wouldn't mind a setting for only activating over a certain speed (like 30-45mph). I've never had it go off (at highway speed) without genuinely moving over in a lane too much.
That said, I do find it activates erroneously for some asphalt repairs, which is annoying, but it's still a great safety feature. This is also a good discussion to have because if it's too aggressive, people will just turn it off. And that's worse than lower sensitivity.