Elevation change or head wind perhaps. If you enter the destination into the Tesla Navigation system you can display the estimated remaining battery charge when you reach the destination. While driving along the route you can view the actual and estimated consumption on the energy screen.
Normally on relatively flat terrain additional passengers and cargo won't make much difference. However if the route has you ascending a few thousand feet the additional load will show up in the Wh/mi.
Rain/heavy rain will have a significant impact on your Wh/mile.
Towing a trailer, carrying bicycles on a rack (on the tow hitch) or a cargo container would all impact your Wh/mile.
If none of these, then there is a chance one of the brake calipers is stuck causing the brake pad to rub against the brake rotor. The brake pad and rotor would become very hot (To test this carefully place your bare hand close to but not touching the brake components to feel for any excessive heat while avoiding potential burns to your hand.