Pretty much as others have said, along with inclines, wind and temperature, rain has one of the largest impacts on range. It's effectively because the tires/wheels have to push the denser water out of the way on the road before moving forward. As an aside, summer tires will suffer more than all-seasons because the tread is smaller. Also air with high humidity has greater density than dry air.
It's hard to quantify how much, it depends on other factors, but if you're typically getting 250Wh/mi, light rain alone might increase that to 260 - 270Wh/mi and heavy rain more so. If you combine that with cold, you could end up adding 50Wh/Mi quite easily.