Yes in a 6 seater. I just sold my 22” wheels several weeks ago. I was able to fit all 4-22” wheels with tires into the car. This while having 2 car seats strapped into the middle row. I was able to fold the third row for two wheels and put a third into the well. The last wheel went in between the two monoposts seats.
I’m preparing for a 2 hr drive to the airport tomorrow with 3 adults, 2 kids and luggage for a week. One large suitcase, one medium, two carry on suitcases, a diaper bag, two back packs, a double stroller, and a 20” OEM spare strapped to the middle aisle.
I had to fold half the 3rd row for the large suitcase, but everything else is in the trunk and frunk so all passengers will be comfortable and not crammed. I could probably swap the large suitcase and wheel positions, but the wheel was easier to get in there. For good measure I got the UMC bundle in there but I don’t typically carry mine. You are right that there’s nowhere for any usable compressor with a storage tank to go. A small tire inflator would fit, but not a real compressor.
Again, for normal every day driving. Probably not the best solution. But for a known trip like mine, I don’t think it’s that big of a deal to carry a spare. It’s better than missing a flight waiting for roadside. Two weeks worth of luggage would be tough though..