We just drove from Phoenix, AZ to Lake Tahoe, CA with a Thule T2 Pro XTR (heavy, but secure) and two MTBs on the back of our MY. Full with 4 people and dog. In an ICE car, this trip takes 12.5 hrs if you blast through, driving 75-80 a lot of the way across the desert. Last summer, driving similarly, same people and dog but no bikes, we were able to skip every other charger and it took about 15 hrs (but we had fun while charging, so it's fine).
This time, on the way out, we realized about 80% of the way to the AZ/NV border that we were burning charge so fast we might not even make it. Like 2 mi of range for every mile driven, sometimes more. Slowed considerably, tried to maximize drafting off trucks, etc, turned off the a/c and made it to the charger with about 8 mi of range left - not to mention sweaty and a little freaked out. After that, we hit every intermediate charge stop we could and charged the battery almost all the way, which takes forever. It took us 18 hours to get there, exhausted and nervous about the drive home.
On reflection, we realized speed was probably the biggest factor, compounded considerably by the bikes. If we slowed from 75-85 to around 70 then we didn't have to panic as much. We managed to drop 2 intermediate charges on the way home and didn't charge all the way up in the slow range except for once, where the next stretch was just too sketchy to risk it. The trip home took 16 hours. That's still not pretty, but a big improvement, and we had a lot fewer stress moments.
Moral of the story: Speed kills (your range), especially with bikes.