Why do you want a tire that size on 21x8.5" wheels? What do you hope to get out of it vs stock size? I think conventional wisdom is it won't be good for handling overall, but I haven't tried a setup like that myself.
Have you looked into the overall clearance for a tire of that diameter and width, when mounted at stock offset, front and rear? Especially front knuckle clearance for the larger diameter.
I don't have any offhand knowledge about tire clearance on the Model S, you'll have to look up or measure the answers.