I dropped 9.5lbs per corner on my car and the 0-60 dropped by a full tenth of a second. 3.14sec --> 3.04sec, highly repeatable.
Also professional drivers can absolutely feel a difference in nearly 40lbs of unsprung mass being removed, this happens all the time when manufacturer's are developing sports cars at places like the Nurburgring with pro drivers input during the pre-production phase. If weight didn't make a difference we'd all still be driving around on steelies...
My current wheels are 19x9.5" and 19.4lbs. The 18x9.5" version weights 17.6lbs. A difference of 1.8lbs.
The 265/35/19 tire is 24lbs. The 265/40/18 tire is 27lbs. A difference of 3lbs.
If you're running forged wheels, very often the extra rubber on a smaller wheels weighs more than extra forged aluminum of a larger wheel.