EV trip planner shows it as 10480 feet up and 11762 down.
Yes, but per the elevation plot, it is more downhill than uphill. If it were +10,480 and -0 ft then it would be a drastically different scenario.
I made this drive back in August but I stopped at Bristol (to visit a new-to-me supercharger) as well as Mountain Motorsports in Kodak, TN (to visit a new-to-me destination charger). From Wytheville to Knoxville was 201.6 miles driven and it consumed 202.5 miles of range. Basically the same as the distance driven due to the elevation drop.
201.6 miles driven and 202.5 miles of range consumed
Wytheville, VA -> Bristol, TN
76.5 miles driven
75.4 miles of range consumed
278 Wh/mi
-415 ft elevation change
75 F temps
Bristol, TN -> Mountain Motorsports (Kodak, TN)
89.8 miles driven
88.0 miles of range consumed
268 Wh/mi
-845 ft elevation change
75 F temps
Mountain Motorsports (Kodak, TN) -> Knoxville, TN
35.3 miles drive
39.1 miles of range consumed
309 Wh/mi
-25 ft elevation change
78 F temps