I think we're tripping over a very small semantic difference between "controlled" and "monitored". If there truly was no human intervention, than the "control center" was just a monitoring center, that was ready to take control if need be. I have had more than one flight over oceans, African deserts, etc where other than checking in initially with the controller, getting initial clearance, checking in with to the next controller, etc, ATC had zero new commands to give us. Were they truly air traffic control, or just air traffic monitoring at that point? Again, tiny semantic difference.
So seeing that aside, how significant is this entirely pre-programmed flight? I'll say moderately so. Automated taxi is relatively new. Automated takeoff is the same, but in many ways a higher degree of difficulty (and something that no commercial aircraft has as an autopilot feature AFAIK). Everything after the takeoff is nothing new.
The demonstration conditions, which I didn't see anything about in the article, make all the difference in the world. Was the airport closed to other traffic? Was there a temporary flight restriction in effect to keep other aircraft out? I assume the weather was calm, clear, no storms and low turbulence, etc. Flying in those conditions is relatively "brainless" for even relatively green pilots. It's the fogged in, popcorn thunderstorm, and ATC having everyone stacked up on holding pattern days where we'd really earn our salaries.
So, is this demo interesting? Yeah, kinda. But, to paraphrase Mark Twain, reports of the death of the piloting profession have been greatly exaggerated.