Actually what you're describing is in fact at least 60% more consumption. That's simply impossible if you're saying that that difference is solely due to tires. If you're losing 10% of charge for a particular route and previously you only lost 6% of charge, unless the battery has declined significantly between those two intervals, you are talking about a greater than 60% increase in consumption or another way of looking at it is greater than 60% decrease in overall efficiency. This would imply an astonishing increase in Drag and at highway speeds most energy goes to overcoming drag rather than rolling resistance.
I think you're conflating a bunch of factors including the possibility that the temperatures on the two drives were different, you're comparing old mxms to new ps4s, and there may be other differences too including your speeds, traffic, etc. There's simply no way that a controlled scientific test would show a 60% difference or thereabouts in Watt hours per mile between those two tires even if the PS4s are brand new.
Also I have a Long Range model 3 that we just bought with the MXM4 and the notion that you were able to keep your watt/hrs per mile at 220 while driving at 80 miles an hour is simply impossible. Since 220whrs/mile is below the so-called canonical range number, this would mean that you would exceed the battery's rated range at 80 miles an hour. No one's ever done that. Unless you're talking about going downhill or downwind . What you're saying simply doesn't add up or square up with massive amounts of data.