HD maps are safer for sure, if properly created and maintained.
Karpathy doesn't think HD maps are scalable, and even if they are scaled, they need to be maintained, which may be either cost prohibitive or not reliable enough given human limitations. The funny thing is that many companies are using vision to create rough HD maps, which begs the question: once your vision is good enough, why even use HD maps?
Because vision is processor-intensive. And of course with connectivity, the fleet of cars could constantly update the maps, feeding any discrepancies back to the server. It will take less local processing power to confirm a map detail using vision than to resolve that detail from scratch from raw vision data. So the on-board computer checks and confirms map details, and if the map is wrong in any detail the on-board computer resolves the item and sends a report to the server. Thus the map speeds up the whole process and the fleet constantly upgrades the map. Each car benefits from earlier cars via the map.