I made it 62500 miles before my first flat caused by a pothole in my 2018 P3D with 20's and I live in Ohio. I've driven through Pennsylvania several times as well as Michigan and a PA pothole finally got me last month in the Pocono Mountain region. It damaged the rim and tire in the same relative spot so am positive one of those potholes caused a slow leak. There is even a gaping hole in the sidewall of one of them that I missed for about a week. I suspect it wasn't big and grew over time and the TPMS sensor alerted me to the pressure had dropped to below the setpoint. It was still a slow leak.
It is a combination of bad luck, heavier than normal vehicle, low profile tires, cast wheels, and something nobody mentions - autopilot. Normally when you drive, you see bad sections of road ahead and shift slightly to avoid it. AP will just go right through and the areas we drive over when centered in the lane are statistically more likely to have more wear on the road. It's just a nature of the beast.
With that said, I've switched to forged 18's and love the look and performance even with downgrading from PS4S to PSAS4 (all seasons). I have noticed when driving with my winter 18's the past week a big improvement in efficiency. I made it from Norwalk, Ohio to Tiffin, Ohio with just 11% usage. I've never seen an efficiency so low and my battery range at 100% is around 280ish (started at 310). I had the same efficiency returning. I just put the slightly lighter Titan T-S5's on and haven't driven that route yet, but did notice no appreciable improvement over the 20's going to Toledo and back so some of it probably has to do with the geometric shape of the rims. The winters are flat faced 5 spoke so there is a decent amount of see through on it, but much less than the new ones. The less wind that can get into the rim probably has the bigger impact, which is why the covers are used on aeros.