You can reboot the screen while driving by holding in the 2 buttons on the steering wheel.I don't think car will allow to reboot the system while in drive anyway, just like you can't put it in park while moving/driving. Please correct me if I am wrong.
It is recommended not to do this by Tesla, but it can be done.
Warning
Only restart the touchscreen while the vehicle is stopped and in Park. The car status display, safety warnings, backup camera, etc. will not be visible during the restart.
Model 3 Owner's Manual | Tesla
The overview displays information related to the touchscreen, vehicle, and driving.
www.tesla.com