Assuming the same wheels/tires, the only meaningful difference between the LR and SR, with respect to efficiency, is the reduced weight of the SR. I'm seeing that the SR is 265 lbs lighter, which makes it about 2% more efficient than the LR.
I appreciate your emotion, but the 21" Turbine wheels have very minor effect on rolling resistance. The TIRES you have on your 21" wheels do make a large difference. Also, the 21" wheels have worse AERO than smaller wheels. It's the sticky tires and big spokes cause the reduced range over the smaller wheels at constant speeds. In stop-and-go traffic, the increased inertia of the larger wheels also increases consumption when compared to smaller wheels.
Incidentally, adding 1500 lbs of cargo to the Model S, with non-LRR tires, looks to increase energy consumption at 65 mph from 304 to 339 Wh/mi, a 12% increase. With LRR tires, the consumption increase due to 1500 lbs cargo is from 278 to 305 Wh/mi, a 10% increase.
Don't pay too much attention to the specific numbers here, as I haven't tried hard to refine my Model S energy consumption model. The trends are accurate however. BTW, I'm assuming a Crr of 0.009 for the non-LRR tires and a Crr of 0.007 for the LRR tires.