Another consideration that is often overlooked is heat dissipation. It is likely easier to design a pack with many small cells to get the best thermal cooling. So if you want the absolute best performance AND the ability to maintain that performance, smaller cells are likely part of that design. That design also includes a fantastic cooling system. It does increase the cost. You increase the cell size to reduce costs. So the 4680 while perhaps not quite there yet, should create the lowest-cost packs in time.
There are a lot of other variables to target a specific vehicle and the objectives you want - often objectives that improve one cause another objective to be reduced! Objectives include lower cost, faster charging, longevity, higher power output, higher power output over time (i.e. track time), safety, improved reliability, reduced use of hard-to-obtain minerals, high power density, weight, and more. Different cell sizes, cell chemistry, pack designs, and cooling systems make this a very complex problem to optimize for a specific vehicle. Those companies that don't bother to optimize for a specific vehicle market segment, end up with a non-competitive vehicle (higher cost, lower range, etc.).
