So in the best case scenario, how long does p1 take? i.e. the minimum time span we need to observe the vaccinated to have no serious side effects?
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Coronavirus
- Thread starter Wenche
- Start date
FWIW, this reddit user is saying California hospitals are using hydroxychloroquine in ICUs right now.
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial : COVID19
bkp_duke
Well-Known Member
For anyone that really wants to dive deeper into coronaviruses and the genetic differences between the current identified subtypes:
Coronavirus | Human Coronavirus Types | CDC
Coronavirus Genome Annotation Reveals Amino Acid Differences With Other SARS Viruses
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(20)30072-X#
Probably more than most people want to know, but there is the current "state of the art" for those that want it.
Coronavirus | Human Coronavirus Types | CDC
Coronavirus Genome Annotation Reveals Amino Acid Differences With Other SARS Viruses
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(20)30072-X#
Probably more than most people want to know, but there is the current "state of the art" for those that want it.
bkp_duke
Well-Known Member
I'm not in vaccine development so this is only and educated guess, but I would bet in this case it will be compressed down to 4-6 weeks. Normally these things move a lot slower (6-18 months for Phase 1?). Anything related to the FDA is very bureaucratic.
Then I assume some German/French Euro company can get faster approval in Europe even if their vaccine is similar to US companies'? Then can American people get it before FDA approval? Or FDA can just bend over to approve it by European standard like the Fed Reserve did to some presidential pressure?
bkp_duke
Well-Known Member
The 4-6 week thing is not a time-limit imposed by any agency. This is literally the most optimal estimate to complete a Phase 1 trial. The EU has similar standards and will not move things along any faster than the FDA in this case, since both regulatory bodies are going to be waiting for the researchers to complete their work.
some humor
will at least in NK life goes on
North Korea fires two projectiles in first launches for three months
I will add, North Korea beloved leader is a top class, keeps South Korea motivated to anticipate any outcome.
Conventional, Nuclear, Chemical or Biological.
will at least in NK life goes on
North Korea fires two projectiles in first launches for three months
I will add, North Korea beloved leader is a top class, keeps South Korea motivated to anticipate any outcome.
Conventional, Nuclear, Chemical or Biological.
Causalien
Prime 8 ball Oracle
It's very curious who the contractor is.
It is doubly curious that the contract is not given to multiple different bidder and have the fastest most accurate competitor become the contractor.
dhanson865
Well-Known Member
powertoold
Active Member
First of all, I don't trust anything from NPR. They are understood, even by the media, as radio BY and FOR liberals. They spew anti-conservative rhetoric at every turn. Secondly, based on FACTS and not a liberally biased poll, the states with liberal leadership are the states that are hardest hit by COVID-19. Period! Washington. California. New York. Hmmmm. Did the liberal leadership of those states not see it as a "real threat"? They CANNOT blame that on Trump. I'm not a scientist but I did my research and knew back in mid February that this virus was bad news. The reality is that COVID-19 doesn't give a rat's behind what party you are, what country you are from (or state), what your skin color is, your sexual orientation or if you see it as a threat or blown out of proportion. All it needs is a host. Our world is in crisis and you liberal haters are getting tiresome. Please stop politicizing this! Do you guys EVER get tired of blaming? Enough already!!
TheTalkingMule
Distributed Energy Enthusiast
Glad to see this narrative on the top of Reuters app.
Special Report: How Korea trounced U.S. in race to test people for coronavirus
Testing, modern information technology, and logic is more than enough to control this without locking anything down.
Perhaps we're past the point where that's possible or we are incapable, but it's easily possible.
Special Report: How Korea trounced U.S. in race to test people for coronavirus
Testing, modern information technology, and logic is more than enough to control this without locking anything down.
Perhaps we're past the point where that's possible or we are incapable, but it's easily possible.
Today China, South Korea and Japan have significantly higher numbers than the last few days. Maybe they just got lucky with their initial response. Coronavirus Update (Live): 219,387 Cases and 8,970 Deaths from COVID-19 Virus Outbreak - Worldometer
It’s easier when the country is in lockdown. In France and Belgium you get fined if you are on the street violating the social distancing rules. Although there weren’t many people violating this on our first day of lockdown, people are scared enough to be careful. Lot’s of police available to enforce this since their other tasks (e.g. traffic related) are not needed for the moment.
Causalien
Prime 8 ball Oracle
There's basically a wave of citizens and residents returning to their home countries right now. Every country is going to see an increase in cases as their students and tourists from Europe and USA return home before the whole world locks down. It is just more pronounced because these countries have so few new cases. In countries with lots of cases, it's just a blip on the radar.
What's interesting is the percentage of these returning citizens that are infected. They are higher than the initial wave of infected from China.
Apparently ALL of the new cases in China are returning people that have been put in quarantine. Not a single new domestic case: China telt geen nieuwe besmettingen meer
ProfTournesol
Member
it is also used in NL for serious patients, got confirmation yesterday form an IC doctor at the Tilburg Hospital. Als if the patient is really serious, they use HIV medicine.
bhtooefr
Active Member
From main:
But why is that?
People dying from being displaced and losing healthcare benefits is because they can't afford to pay for those things due to loss of income and healthcare being tied to employment.
Outside of things specifically needed to treat this pandemic, as well as labor needed to treat it, there's no actual shortages of necessary goods. (There is hoarding causing massive unsustainable demand spikes, but the actual necessary supply is fine.) For that matter, there's plenty of labor still going into unnecessary goods that could be redirected.
The government has immense powers that, if it chooses to use them, would allow it to entirely prevent those deaths. Pass Medicare for All, and then people won't lose their healthcare coverage (with the caveat that having coverage won't help much if your local healthcare system is beyond capacity) - yes, I know that won't happen, but still. Print money and pay a UBI - which Republicans are proposing - and people won't lose their income. Forbid evictions and foreclosures - already a policy in places - and people won't lose their home, at least for now. You can even directly supply certain goods like food, bypassing the economy entirely.
All of this is action that can be taken right now to prevent the economy from killing people.
The economy is meant to facilitate exchange of goods and services. If the economy is creating artificial scarcity and people are dying as a result, the economy has failed at its mission, and the government can and should step in to prevent that outcome.
But why is that?
People dying from being displaced and losing healthcare benefits is because they can't afford to pay for those things due to loss of income and healthcare being tied to employment.
Outside of things specifically needed to treat this pandemic, as well as labor needed to treat it, there's no actual shortages of necessary goods. (There is hoarding causing massive unsustainable demand spikes, but the actual necessary supply is fine.) For that matter, there's plenty of labor still going into unnecessary goods that could be redirected.
The government has immense powers that, if it chooses to use them, would allow it to entirely prevent those deaths. Pass Medicare for All, and then people won't lose their healthcare coverage (with the caveat that having coverage won't help much if your local healthcare system is beyond capacity) - yes, I know that won't happen, but still. Print money and pay a UBI - which Republicans are proposing - and people won't lose their income. Forbid evictions and foreclosures - already a policy in places - and people won't lose their home, at least for now. You can even directly supply certain goods like food, bypassing the economy entirely.
All of this is action that can be taken right now to prevent the economy from killing people.
The economy is meant to facilitate exchange of goods and services. If the economy is creating artificial scarcity and people are dying as a result, the economy has failed at its mission, and the government can and should step in to prevent that outcome.
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