Not to alarm anyone, but.....
B.1.1.7: Status & Tracking in the U.S.
Bookmark this link:
Helix SARS-CoV-2 Viral Sequencing
Tableau Public
Just a reminder about this Helix link. Florida in the lead, followed by Texas and California. Florida looks to go 50% B.1.1.7 by mid-March.
If you squint, you could probably argue that Florida seems to be struggling to bring down their cases, as compared to other states. B.1.1.7? Maybe.
Texas is a bit harder to gauge due to recent irregularities in the data from the storm.
New York and New Jersey also are showing trends in the wrong direction. (Not sure whether it has anything to do with that local variant there that we don't know much about.)
Places like North Dakota, really hard hit and hitting it hard with the vaccine, are doing very well and are probably past the point of any concern for resurgence (assuming no immune escape).
Just need to keep pumping out that vaccine and getting it into arms.
To put in perspective, we went from 12% of population infected to 25% in 2.5 months in a massive surge. It look a month of explosive growth (from the levels we are currently at) to hit 4% of the population. Future outbreaks will be less explosive due to increased levels of immunity. They could still be massive. But it takes time. We'll vaccinate over 10% of the population in the next month (at least 5x as many people as get infected).
So: Time is (for the most part) on our side. That's what the projections are saying (
Path to Herd Immunity - COVID-19 Vaccine Projections) It says that we'll probably double our case level (with lower mortality) from current levels (he's having to adjust his vaccination numbers up so this may be pessimistic). And then we'll be mostly done. Another ~23k deaths from an additional 15 million infections (assuming IFR of 0.15% going forward),
not counting deaths from ongoing, current, infections and deaths not yet reported (a much higher total). Bad, but not like what we have been through.
I think the magnitude of that peak is dependent on vaccinations, for the most part, with a small contribution of what restrictions are in place.
And of course the worst-case scenario of rampant immune escape (still no evidence of that happening in vaccinated individuals), with no protection from death from vaccination, is not assumed here.
Good news: vaccines generated for the the South African B.1.351/501Y.V2 variant likely will be quite "backwards compatible." Neutralizing titers from convalescent plasma against the original virus were only reduced a factor of 2.3x relative to the original plasma response. (A 4.1x decline relative to the 501Y.V2 response, the reason for the discrepancy being a stronger response in general to 501Y.V2)
Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma
So this suggests that the future vaccine boosters might be able to have a single component, though who knows what they'll decide to actually do.
More discussion:
https://twitter.com/sailorrooscout/status/1367085609072939019?s=20