Most people adjust vents. And at the risk of sounding sexist, my experience has been that females are more sensitive to temperature variation than men. As soon as my wife, mother, and mother-in-law get in a car in the summer, they aim every vent away from them. Alternatively, I aim them directly at myself until I'm cool at which point I'll adjust. Gender related or not, people have different preferences on temperature and airflow. I am surprised to hear that some people set them and forget them.