Coronavirus

[SageBrush]

Trump says he’s taking hydroxychloroquine in case he gets coronavirus

Give that monkey a grapefruit

 

[Papafox]

"Hahahaha Trump is taking hydroxychloroquine. Why doesn't he just inject bleach. Hahahahahaha"

OK, you've had your fun, but just remember that the Chinese got interested in chloroquine for COVID19 when they noticed the lupus patients in their hospitals weren't catching the virus, and we all know what lupus patients take.

What we really need is for one of the controlled studies of HCQ as a prophylactic to be completed. Until then the jury is still out.

 

[TespaceX]

Eric Trump Claims Social Distancing Is a Democrat 'Strategy' and COVID-19 Will 'Magically' Disappear After Election
Like father, like son.
We should propose moving up the election to next month and just get this whole virus matter over with, and we can all live happily ever after then.


Very conservatively, I say that at least 1/3 of all of America still believe this is all a nothingburger.
Get ready for wave 2, or phase 2 of wave 1, whichever you like to call it.

 

[bkp_duke]

From a Lupus web page.
Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus pa....

Point is, Its a slow medication, best used before exposure not after...

Not applicable. That's slow-acting because Lupus is an autoimmune disease.

The drug itself reaches steady state after dosing in about 3-5 days.

 

[renim]

Not applicable. That's slow-acting because Lupus is an autoimmune disease.

The drug itself reaches steady state after dosing in about 3-5 days.

Now that I would be really interested in, a family member was on that stuff for lupus and i doubt their blood concentration was steady state after 3-5 days for that regime. If you have any sources i would appreciative.

Hydroxychloroquine Blood Levels in SLE: Clarifying dosing controversies and improving adherence

 

[TheGrimSweeper]

Worldometers has recently added some mortality / IFR and other calculations.
Coronavirus Death Rate (COVID-19) - Worldometer

Using numbers from New York City, they calculated an IFR of 1.4% :

I was looking forward to this todya and happy to see they seperated out under 65 with no health concerns

0.09% chance of death for under 65 with no preexisting conditions.

I think we can start going back to work

 

[bkp_duke]

Now that I would be really interested in, a family member was on that stuff for lupus and i doubt their blood concentration was steady state after 3-5 days for that regime. If you have any sources i would appreciative.

Hydroxychloroquine Blood Levels in SLE: Clarifying dosing controversies and improving adherence

That is missing the point, and think I understand why. I believe you are assuming that inflammation related to Lupus responds instantly to HCQ. That is an erroneous assumption, as inflammatory processes are multi-factoral and are notorious for taking time (weeks to months) to respond to medications.

Antibacterial or antiviral responses, however, must be much faster.

This paper shows that just 1 hour after HCQ ingestion you have good levels in the blood stream. To keep those up, you have to continue the dosing to counteract clearance of the drug.

https://www.ahajournals.org/doi/full/10.1161/01.cir.96.12.4380




EDIT - too bad we know this medicine, despite hitting good blood levels, doesn't do anything for COVID-19.

 

[traxila]

"Hahahaha Trump is taking hydroxychloroquine. Why doesn't he just inject bleach. Hahahahahaha"

OK, you've had your fun, but just remember that the Chinese got interested in chloroquine for COVID19 when they noticed the lupus patients in their hospitals weren't catching the virus, and we all know what lupus patients take.

What we really need is for one of the controlled studies of HCQ as a prophylactic to be completed. Until then the jury is still out.

I know someone who was on HCQ for lupus and got COVID. Anecdotals are just that unfortunately.

 

[TheTalkingMule]

Posting stuff like this is beyond the pale. If you don’t understand the different MOAs involved in the two treatments then be silent and try to learn something.

Just because Trump admits he is a moron you don’t have to jump on the bandwagon.

Do you think there are people reading this thread, let alone listening to the medical opinions provided?

 

[bkp_duke]

Do you think there are people reading this thread, let alone listening to the medical opinions provided?

Ahem . . .

 

[jerry33]

Ahem . . .

View attachment 542804

I've recommended this page to several people.

 

[SageBrush]

Trumper Confession.
He easily forgives himself

A Florida man who initially said he believed the coronavirus was a “fake crisis” that was “blown out of proportion” is now hospitalized with the virus, along with his wife, and he has a warning for others.

“Many people still think that the Coronavirus is a fake crisis which at one time I did too and not that I thought it wasn’t a real virus going around but at one time I felt that it was blown out of proportion and it wasn’t that serious,” Brian Hitchens wrote in a lengthy Facebook post last Tuesday.

Hitchens said he continued to downplay the pandemic until he began feeling sick and couldn’t work anymore, KTLA sister station KRON reported Monday.

Just days after he became sick, Hitchens said his wife also started feeling sick, went to a hospital and was told to self-quarantine.

Their conditions worsened, and they were admitted into a local medical center.

“They admitted us right away, and we both went to ICU. I started feeling better within a few days, but my wife got worse to the point where they sedated her and put her on the ventilator,” he said.

He said he was never put on a ventilator.

“Never had terrible aches and pains just weak and exhausted,” Hitchens said, adding that his wife remains sedated.

“After 3 weeks I have come to accept that my wife may pass away and the peace I have about it is that I know without a shadow of a doubt that she will be going home to be with the Lord but I also do believe in miracles and I’m holding on to the chance that she may get healed but if not I am thankful for her I know we’ve been married for 8 years,” he said.

He added, “So think about what I wrote and think about if this thing is a fake crisis.”

“Looking back I should have wore a mask in the beginning but I didn’t and perhaps I’m paying the price for it now but I know that if it was me that gave it to my wife I know that she forgives me and I know that God forgives me,” he added.

 

[madodel]

I've recommended this page to several people.

So you made it go viral?

 

[HG Wells]

White House physician confirms he is treating Trump with hydroxychloroquine.

Trump ‘is in very good health’: White House doc explains why the president is taking hydroxychloroquine.

Trump ‘is in very good health’: White House doc explains why the president is taking hydroxychloroquine

SEE even doctors recommend it ! /S

 

[SageBrush]

What we really need is for one of the controlled studies of HCQ as a prophylactic to be completed

After the inpatient RCT was stopped early due to excess mortality in the HCQ arm, I find it a bit hard to believe that any are continuing.

 

[Dr. J]

Trump says he takes hydroxychloroquine to prevent coronavirus infection
Trump says he takes hydroxychloroquine to prevent coronavirus infection even though it isn't a proven treatment


Lolololololololol

 

[renim]

That is missing the point, and think I understand why. I believe you are assuming that inflammation related to Lupus responds instantly to HCQ. That is an erroneous assumption, as inflammatory processes are multi-factoral and are notorious for taking time (weeks to months) to respond to medications.

Antibacterial or antiviral responses, however, must be much faster.

This paper shows that just 1 hour after HCQ ingestion you have good levels in the blood stream. To keep those up, you have to continue the dosing to counteract clearance of the drug.

https://www.ahajournals.org/doi/full/10.1161/01.cir.96.12.4380

View attachment 542791


EDIT - too bad we know this medicine, despite hitting good blood levels, doesn't do anything for COVID-19.

Thanks for the paper, to me it is indicative of how HCQ can be protective during the disease state of Covid19 even if it nothing against the virus itself.

Its just a theory, and the model is that the lung's Capillary blood vessels are the real covid19 damage. Point is, if HCD has a role in reducing size and duration of thrombosis in mice, perhaps the same can apply in human's lungs.

Would i want to start experimenting with QT altering medications once heart damage is starting? No.

The Minnesota Post-exposure Prophylaxis / Preemptive Therapy for SARS-Coronavirus-2 - Full Text View - ClinicalTrials.gov HCD study will take take months after study completion date due to observation requirement. And even then, its just one factor, the Chinese like their drug cocktails, and if it requires a synergistic effect to be effective, well that just takes more and more time to demonstrate.

 

[SageBrush]

It is amazing to me that the difference between USA having a functioning economy and low morbidity/mortality from Covid-19 -- Vs the cluster going on now is a willingness to wear masks in public, engage in personal hygiene, and have a federal executive not mired in insanity.

Too much to ask, obviously

 

[scottf200]

I know someone who was on HCQ for lupus and got COVID. Anecdotals are just that unfortunately.

... but just remember that the Chinese got interested in chloroquine for COVID19 when they noticed the lupus patients in their hospitals weren't catching the virus, and we all know what lupus patients take.

I follow Lupus issues and I am not buying the Chinese anecdotal note above.

Lupus . org site: Are People with Lupus Protected Against COVID-19?

Are People with Lupus Protected Against COVID-19?
There is no evidence that taking hydroxychloroquine (Plaquenil) is effective in preventing a person from contracting the coronavirus (COVID-19).
...
There are no currently available data from Randomized Clinical Trials (RCTs) to inform clinical guidance on the use, dosing, or duration of hydroxychloroquine for prophylaxis or treatment of SARS-CoV-2 infection.

 

[Unpilot]

Thanks for the paper, to me it is indicative of how HCQ can be protective during the disease state of Covid19 even if it nothing against the virus itself.

What??