This is a very timely thread for me! I live in the Virginia countryside, but for this month only I need to do a daily commute 55 miles and back into DC taking I66, where my timing is such that I avoid the HOV-only period on that road inside the beltway. I finally appreciate AP (which in my case is AP1).
My setting choice has mainly been 2, occasionally 1, because it most closely emulates the behavior of other drivers (or at least the more conservative 75%). I often break out of AP into manual where there is aggressive merging from an interchange ahead of me. Setting 2 can work fairly well with merging except where a car merges ahead of me with slower speed than mine. Then AP brakes harder than I would to maintain its distance. Similarly, my only real criticism of AP is that it brakes sooner and harder than I would when the car ahead slows down. My fear is that it would back me up into, or brake-check, the driver following behind. In fact part of the reason I use 1 or 2 is that the driver behind me then tends to follow at normal distance, while leaving a big gap ahead by using 4 or higher tends to cause the driver behind to follow very close due to frustration or to send a message. That increases my worry about sudden or premature braking. On faster sections, 2 seems to leave a decent gap in front, while out where I live, where the speed limit is 70 and cars are near 80, I tend to drive manually if there is any traffic at all.
Overall, AP has been great on this commute so far.